B-590.16.112 [2020-10] Glucose – Enzymatic Method

The extract content of normal beer wort is typically composed of around 90 % carbohydrates, which occupies the position of highest importance for beer production.

The starch reserves originally found in the barley kernel are converted to some extent into soluble carbohydrates by degradation during malting; however, the majority of soluble carbohydrates are released during mashing. The products of starch degradation can be classified into three groups:

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The determination of glucose is of particular importance in the analysis of...

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Application/Purpose

Determination of glucose by enzymatic means

 

Scope of Application

Suitable for beers, mixed beer beverages, malt beverages and NAB

 

Principle

Glucose is phosphorylated by the enzyme hexokinase (HK) and adenosine 5'-triphosphate (ATP) to glucose 6-phosphate (G-6-P)

\(\text{Glucose + ATP} \space ^{\underrightarrow{\text{HK}}} \space \text{G-6-P + ADP}\)

In the presence of the enzyme glucose-6-phosphate dehydrogenase (G6P-DH), G-6-P is oxidized by nicotinamide adenine dinucleotide phosphate (NADP) to gluconate-6-phosphate. Reduced nicotinamide adenine dinucleotide phosphate (NADPH) is formed:

\(\text{G-6-P + NADP} \space ^{\underrightarrow{\text{G6P-DH}}} \space \text{gluconate-6-phosphate + NADP + H}^+\)

The amount of NADPH formed during the reaction is equivalent to the amount of glucose. NADPH is determined based upon its absorbance at 334, 340 or 365 nm.

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